Retinoblastoma Protein Prb

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The retinoblastoma protein (protein name abbreviated pRb ; gene name abbreviated RB or RB1 ) is a tumor suppressor protein that is dysfunctional in several major cancers . [3] One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, becomes inactive and allows cell cycle progression. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases. [4]

Rb and cell cycle machinery. Rb and Rb-p represent the unphosphorylated and the phosphorylated forms of the retinoblastoma protein. In G0 and early G1, Rb physically associates with E2F factors and blocks their transactivation domain. In late G1, Rb-p releases E2F, allowing the expression of genes that encode products necessary for S-phase progression.

Retinoblastoma protein; p105-Rb Protein; Rb Protein; Retinoblastoma ...

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