Retinoblastoma Protein Prb

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The retinoblastoma protein (protein name abbreviated pRb ; gene name abbreviated RB or RB1 ) is a tumor suppressor protein that is dysfunctional in several major cancers . [5] One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, becomes inactive and allows cell cycle progression. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases. [6]

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Retinoblastoma Protein

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